LAUSR

Objective The prevalence of hyperuricemia appears to be high worldwide. We aimed to explore the interaction between harmful alcohol use and tea consumption on hyperuricemia. Methods This study recruited 22,449 Han residents based on the data from the China Multi-Ethnic Cohort (CMEC) study, Chongqing province, to have a face-to-face electronic questionnaire, physical examination, and clinical laboratory tests. The difference in hyperuricemia between the different populations was compared by the Chi-square test. The interaction between harmful alcohol use and tea consumption was analyzed by the multivariate logistic regression model. Results Amongst 22,449 participants, the mean age was 51.5±11.8 years, and 46.83% of them were males. The proportion of harmful alcohol use, tea consumption, and harmful alcohol use and tea consumption were 14.01%, 21.01%, and 6.54%, respectively. Multivariate logistic regression showed that the odds ratio (OR) of harmful alcohol use and tea consumption (OR=2.21, 95% CI: 1.58–3.10) was greater than that of harmful alcohol use (OR=1.63, 95% CI:1.17–2.27) and tea consumption (OR=1.34, 95% CI:1.10–1.63). Among males, the results were similar (harmful alcohol use and tea consumption: OR=2.02, 95% CI: 1.43–2.84; harmful alcohol use: OR=1.61, 95% CI: 1.14–2.27; tea consumption: OR=1.28, 95% CI: 1.05–1.57). However, among females, the odds ratio of harmful alcohol use and tea consumption (OR=15.50, 95% CI: 1.36–176.50) was more than 10 times than that of only harmful alcohol use (OR=1.55, 95% CI: 0.42–5.69) or tea consumption (OR=1.22, 95% CI: 0.52–2.82). Conclusion The interaction of harmful alcohol use and tea consumption was a positive risk for hyperuricemia in Han residents aged 30–79 years in China.