LAUSR

I recently read an original article by Ma et al titled “Association of Stress Hyperglycemia Ratio and in-Hospital Mortality in Patients with Sepsis: A Two Center Retrospective Cohort Study”. 1 This is a very valuable and significant study in the field of medicine. It is an early or the first study to examine the relationship between Stress Hyperglycemia Ratio (SHR) and mortality in septic patients, and provides timely identification of septic patients who are at higher risk of in-hospital mortality so that appropriate clinical decisions can be made. Given the high risk of mortality in septic patients and the severe burden it places on global health systems, 2 it is the responsibility and mission of healthcare professionals to enhance the in-hospital management of septic patients. This paper is well written, with a sound study design, proper methodology, and abundant results. The authors used various methods to explore the relationship between SHR and in-hospital mortality of sepsis patients, such as multi-factorial logistic regression analysis, Kaplan–Meier survival analysis, Cox regression analysis, and subgroup analyses, which led to more reliable conclusions. In the discussion section, the authors explained in detail the potential mechanisms by which controlling SHR within reasonable limits may improve patient prognosis. Several aspects of improvement still exist in this study for reference.