LAUSR

Introduction COVID-19 has been a global public health problem since December 2019. Higher education institutions are risky areas for the transmission of COVID-19. But, still there is insufficient information on the prevention of the disease in this setting. Objective To assess knowledge, attitude, and prevention practices towards COVID-19 among students of Ethiopian higher education institutions. Methods Institutin -based cross-sectional study design was conducted from December 1 to 30, 2020 among randomly selected 407 undergraduate students from higher education institutions in Ethiopia. The outcome variables were knowledge, attitude, and practices towards COVID-19. Binary logistic regression models at 95% confidence interval (CI) were used to determine the factors affecting knowledge, attitude, and practices towards COVID-19. In multivariable analysis, variables with a p-value of less than 0.05 were considered statistically significant and independently associated with outcome variables at 95% CI. Results About 75.9% (95% CI: 72.2–79.9%) of University students had a good knowledge, 62.4% (95% CI: 58.2–67.1%) had a positive attitude, and 56.8% (95% CI: 52.6–61.9%) had a good COVID-19 prevention practices. Students over the age of 30 (AOR=5.8; 95% CI: 1.5, 10.6), third-year students (AOR=3.1; 95% CI: 1.1, 8.9), and being health science students (AOR=4.4; 95% CI: 2.2, 8.9) were significantly associated with a good knowledge towards COVID-19. Urban residents (AOR=0.6; 95% CI: 0.3–0.9), having an average family monthly income of $75USD (AOR=3.5; 95% CI: 1.8–6.7), use of at least one type of social media (AOR=4.7; 95% CI: 1.7–12.9), and having a positive attitude (AOR=2.2; 95% CI: 1.3–3.5) were significantly associated with COVID-19 prevention practices. Conclusion Despite three-fourths of the participants had a good knowledge, the attitude and prevention practices were low. Age, study year, College of study, presence of chronic illnesses, use of social media, family income, and residence were factors of knowledge, attitude, and prevention practices towards COVID-19. Hence, multiple information dissemination strategies using multiple media outlets should be implemented continuously.