LAUSR

I thoroughly reviewed Bao et al’s article 1 on “Major Infections of Childhood-Onset Systemic Lupus Erythematosus” in the Journal of Multidisciplinary Healthcare. This retrospective study analyzed 98 cSLE patients to identify risk factors and develop a prediction model for major infections within 6 months of diagnosis. High disease activity, lupus nephritis, serositis, and lymphopenia increased the infection risk. The CALL score (Children with high disease activity, lymphopenia, and LN) effectively identifies high-risk patients. Early identification using the CALL score aids in managing major infections in cSLE patients. 1 The authors acknowledge the retrospective nature of the study, the small number of participants, incomplete or delayed vaccination status, and identifying infections using diagnosis codes as limitations. However, there are additional limitations that should be addressed. 1