LAUSR

Purpose A number of studies have investigated the role of DJ-1 in the development and progression of malignant tumors. This meta-analysis aims to systematically estimate the rela-tionship between the expression level of DJ-1 and the malignant biological behaviors of tumors and to assess the clinical significances of DJ-1 in the prognosis and diagnosis of cancer. Materials and methods We searched PubMed, Web of Science, China National Knowledge Infrastructure and Wanfang databases from inception to December 1, 2017. Pooled odds ratio (OR) and hazard ratio (HR) with their 95% confidence interval and the diagnostic value of DJ-1 were calculated. Results Fourteen eligible studies with a total of 1,947 subjects were enrolled in our meta-analysis. The results showed that DJ-1 was overexpressed in cancer patients compared with noncancer patients (OR = 30.72), and elevated expression of DJ-1 was demonstrated to be closely associated with high tumor-node-metastasis stage (OR = 5.52), poor differentiated degree (OR = 2.46), positive lymph node metastasis (OR = 4.12) and worse overall survival (HR = 2.23). In addition, the combined sensitivity and specificity for DJ-1 to discern malignant tumors were 0.73 and 0.93, respectively. The diagnostic OR was 34.87, and the area under the summary receiver operating characteristic curve was 0.88. Conclusion This meta-analysis demonstrated that DJ-1 was an important biomarker in tumor assessment and prognosis prediction.