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Studies Toward the Synthesis of Caramboxin Analogues

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Intrigued by the recent discovery of caramboxin by Brazilian researchers, we present the results from our studies toward the racemic synthesis of caramboxin analogs through the orthocarboxylation of 3,5-dimethoxy benzyl… Click to show full abstract

Intrigued by the recent discovery of caramboxin by Brazilian researchers, we present the results from our studies toward the racemic synthesis of caramboxin analogs through the orthocarboxylation of 3,5-dimethoxy benzyl derivatives. Three different approaches were tested, and the route involving a Vilsmeier-Haack formylation followed by a Lindgren oxidation provide a potential intermediate for the synthesis of several caramboxin analogs.

Keywords: studies toward; synthesis caramboxin; caramboxin; caramboxin analogues; toward synthesis; synthesis

Journal Title: Journal of the Brazilian Chemical Society
Year Published: 2018

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