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Idiopathic thrombocytopenic purpura (ITP)is a bleeding disorder with an unclear etiology ,The most common hemorrhagic autoimmune disease, and characterized by isolated thrombocytopenia that is not accompanied by any other disorders that may lead to thrombocytopenia. Interleukin-23 (IL-23) is a member of the IL-12 family; it is primarily secreted by activated dendritic cells, Monocytes, and macrophages and has important implication in the pathogenesis of many autoimmune diseases. The aims of this study was to evaluate the role of IL-23 in diagnosis of idiopathic thrombocytopenic purpura. A total of 5 papers were obtained using the mentioned keywords in the research of all internetbased databases. The total number of cases in all of the studies was 239 cases. The mean age was recorded in 5 papers, and the mean age of each of them was 32.8 years. There are different method of detection of IL23 in different studies such as PCR, ELISA and flow cytometry These findings suggest that levels of IL-23 are significantly higher in ITP patients. Introduction Immune thrombocytopenia(ITP) is autoimmune destruction of platelets in addition to suppression of platelet production by the bone marrow (BM) megakerocytes (Neunert,2013). The cellular immunity deficiency plays an important role in the pathogenesis of ITP, including B-cell activation ,T-cell related disorders and antigen-presenting cell functional defect (Semple JW, et al, 2010)Significantly, it is well-recognized that an abnormal T-cell-mediated response is strongly correlated to the development and progress in ITP (Semple JW, et al, 2012 ). Interleukin 23 (IL23 ), which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35(Gee K, et al ,2009).IL23 is a heterodimeric cytokine, composed of a p19 subunit and a p40 subunit ;it binds IL-23R and IL12Rβ1,the latter being shared with IL12 (Suzuki et al.,2014).The p40 subunit can act as amonomer ,homodimer or as a heterodimer with p19 ,and both subunits are secreted predominantly by macrophages and dendritic cells (DCs) (Suzuki et al.,2014 and Oppmann et al.,2009) IL-23 is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis(Lubberts E, et al, 2008), primary biliary cirrhosis(Qian C, et al, 2013), and inflammatory bowel disease (Fransen K, et al ,2014) Objectives: This study is designed to review the role of IL-23 in diagnosis of idiopathic thrombocytopenic purpura . Strategy and methods The strategy of this systematic review will be based upon raising some research questions addressing the different techniques of role of IL23 in ITP and put a plan to find the best available answers for each. This will be done by looking in PDF created with pdfFactory Pro trial version www.pdffactory.com SOHAG MEDICAL JOURNAL The Role of IL-23 in Patients with Idiopathic Vol. 21 No.3 october 2017 Omnia Safwat Fathy.et al 154 the literature and critically appraising the available researches in this field. Good quality researches will be selected to reach a conclusive answer for each question. The research questions are: 1I s there an evidence-based value of IL 23 in diagnosis of ITP? 2I s there any evidence of dexamethasone in the level of IL23 before and after treatment? 3ow can we detect the level of IL23 ? Selection criteria of the available researches: a) Type of study: systematic review. b) Time of studies: studies had been published during the last five years from first of January 2012 to 31 December 2016 . C) Sites visited:Cochrane library, PubMed, Medline, Science direct, any other site containing useful information b)