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Disseminated Bacillus Calmette-Guerin Infection with Rhabdomyolysis, Acute Kidney Injury, and Interstitial Pneumonia after Bacillus Calmette-Guerin Intravesical Instillation Therapy.

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A 79-year-old man experienced a fever and immobility after receiving 6 doses of Bacillus Calmette-Guerin (BCG) intravesical instillation therapy for bladder tumor. Rhabdomyolysis and acute kidney injury occurred; therefore, hemodialysis… Click to show full abstract

A 79-year-old man experienced a fever and immobility after receiving 6 doses of Bacillus Calmette-Guerin (BCG) intravesical instillation therapy for bladder tumor. Rhabdomyolysis and acute kidney injury occurred; therefore, hemodialysis was performed. His kidney function was restored. However, he exhibited an inflammatory reaction that was resistant to broad-spectrum antibiotics and eventually developed interstitial pneumonia. Corticosteroid treatment partially relieved the symptoms of interstitial pneumonia, although disuse syndrome persisted. He was diagnosed with disseminated BCG infection through sputum culture. BCG infection shows various symptoms and is difficult to diagnose microbiologically. It should be suspected when systemic symptoms occur after BCG intravesical instillation therapy.

Keywords: instillation therapy; intravesical instillation; calmette guerin; bacillus calmette; interstitial pneumonia

Journal Title: Internal medicine
Year Published: 2023

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