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A Case of Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype that Developed after a Uterine Cancer Test.

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A 69-year-old woman without pre-existing disease visited our hospital due to general malaise, diarrhea, and arthralgia 3 days after a uterine cancer test. We diagnosed her with sepsis of unknown… Click to show full abstract

A 69-year-old woman without pre-existing disease visited our hospital due to general malaise, diarrhea, and arthralgia 3 days after a uterine cancer test. We diagnosed her with sepsis of unknown focus and started treatment immediately, but she died 20 h after the first visit due to multi-organ failure and septic shock. Later, group A streptococcus was detected from the blood culture, and streptococcal toxic shock syndrome (STSS) was diagnosed. The strain had the emm28 genotype and a mutation in csrR with increased NADase activity. These virulence factors were considered to be related to STSS development in this patient.

Keywords: cancer test; uterine cancer; toxic shock; group streptococcus; streptococcal toxic; shock

Journal Title: Internal medicine
Year Published: 2021

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