LAUSR

BACKGROUND The incidence of allergy is increasing at an alarming rate for the last few decades. OBJECTIVE Our present study is focused on finding out the structurally homologous motifs present in different proteinaceous allergens Methods: Significant number of protein sequences and their corresponding structures of various pollen, fungal, bacterial, and food allergens were retrieved, and the sequence and structural identity were analyzed. RESULTS Intra- and inter-sequence and their structural analysis of the proteinaceous allergens, resulted in no significant relationships among them. A few, but not negligible number of high structural similarities were observed within different groups of allergens from fungus, angiosperms, and animals (Aves and Mammalia). CONCLUSION Our in silico study on thirty-six different allergens showed a significant level of structural similarities among themselves, regardless of their sequences.