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Coronavirus are pathogens that seriously affect human and animal health. They mostly cause respiratory or enteric diseases, which can be severe and life threatening, such as coronavirus disease 2019 (COVID-19),… Click to show full abstract
Coronavirus are pathogens that seriously affect human and animal health. They mostly cause respiratory or enteric diseases, which can be severe and life threatening, such as coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome (SARS), and Middle East Respiratory Syndrome (MERS) in humans. The conserved coronaviral papain-like protease is an attractive antiviral drug target because it is essential for coronaviral replication and it also inhibits host innate immune responses. This review focuses on the latest research progresses relating to the mechanism of coronavirus infection, the structural and functional characteristics of coronavirus papain-like protease, and the potent inhibitors of the protease.
Journal Title: Protein and peptide letters
Year Published: 2022
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