LAUSR

Cancer stands as one of the leading causes of death worldwide and affects a wide range of organs and cell types. While incipient cancer tumors often benefit from curative surgical therapy, metastatic cancer requires aggressive therapeutic options. Frequent flaws in cancer chemotherapy are due to non-selective tissue toxicity, drug-resistance and severe systemic side-effects. These limitations can be addressed by a more precisely targeted delivery systems designed to incorporate anticancer agents. Such delivery systems can be provided by nanotechnology which introduces advantages related to high surface/mass ratio and has the potential to enhance the bioavailability of anticancer agents and improve their pharmacokinetic profile. Various types of nanoformulations were designed and aassessed, revealing the opportunity of targeting selected tissues/regions thus increasing the anti-tumor activity and minimizing the systemic toxic effects. This special issue compiles three review articles that aimed at widening the current knowledge on nanoparticulated formulations with anticancer applications.