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Benzimidazole-derived compounds designed for different targets of Alzheimer's disease.

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Benzimidazole scaffold has been efficiently used for the design of various pharmacologically active molecules. Indeed, there are various drugs, available today, employed for the treatment of different diseases. Although, there… Click to show full abstract

Benzimidazole scaffold has been efficiently used for the design of various pharmacologically active molecules. Indeed, there are various drugs, available today, employed for the treatment of different diseases. Although, there is no benzimidazole moiety containing drug available today for the treatment of Alzheimer's Disease (AD), there have been many benzimidazole derivative compounds designed and synthesized to act on some of the validated and non-validated targets of AD. This paper has aimed to review the literature to describe these benzimidazole containing molecules designed for the treatment of AD.

Keywords: alzheimer disease; benzimidazole derived; compounds designed; derived compounds; benzimidazole

Journal Title: Current medicinal chemistry
Year Published: 2019

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