LAUSR

Ferroptosis plays a critical regulatory role for a new kind of cell death initiating and developing an array of disorders like neurological diseases, acute injury of kidney, tumors and ischemia etc. This selective deposition of iron is one of the pathogenic reasons for PD and although it's underlying mechanism is still unknown. In this review, the role of neuroinflammation in Parkinson's disease (PD) leading to neurodegeneration has been discussed in detail. The accumulation of brain iron has been found in many chronic neurological disorders including PD. We have also discussed the unique features of Ferroptosis as compared to other cellular death pathways and it links in aggravating the pathology of PD. Further, the concept of targeting Ferroptosis for PD pathology and inducers and inhibitors, pharmacological drugs and clinical trials for PD candidates in phase IV stage in completed status are detailed in the respective sections.