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The tricarboxylic acid (TCA) cycle is the center of energy metabolism in eukaryotic cells and dynamically adjusted according to energy needs of cells. Macrophages are activated by inflammatory stimuli, and… Click to show full abstract
The tricarboxylic acid (TCA) cycle is the center of energy metabolism in eukaryotic cells and dynamically adjusted according to energy needs of cells. Macrophages are activated by inflammatory stimuli, and then two breakpoints in TCA cycle lead to the accumulation of intermediates. Atherosclerosis is a chronic inflammatory process. Here, the "non-metabolic" signaling functions of TCA cycle intermediates in the macrophage under inflammatory stimulation and the role of intermediates in the progression of atherosclerosis were discussed.
Journal Title: Current medicinal chemistry
Year Published: 2021
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