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Novel Pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as Protein Kinase C Inhibitors for Treating Diseases.

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This patent describes the series of compounds and their pharmaceutically acceptable salts, such as compound K7 (as a representative potent compound). These protein kinase C selective inhibitors are useful for… Click to show full abstract

This patent describes the series of compounds and their pharmaceutically acceptable salts, such as compound K7 (as a representative potent compound). These protein kinase C selective inhibitors are useful for treating diabetes mellitus and its complications, cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease, dermatological disease pression, virus diseases, inflammatory disorders, or diseases in which the liver is a target organ.

Keywords: protein kinase; pyrimidin amino; pyrrolo pyrazoles; pyrazoles protein; amino pyrrolo; novel pyrimidin

Journal Title: Current medicinal chemistry
Year Published: 2023

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