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Editorial Novel Targets for Therapeutic Intervention in Inflammatory Bowel Disease: Research Drives Clinic Over the past years, Inflammatory Bowel Disease (IBD), has become one of the most innovative chapters in Gastroenterology. Not only because its frequency has been exponentially rising worldwide, but mainly due to a great improvement on the knowledge about the diversity of immunologic mechanisms, leading to multiple inflammatory pathways, involved in the physiopathology of the disease, thus, making it possible to develop novel drugs targeting several steps of this “spider web”. Moreover, IBD is of great interest because of its impact on the quality of life of affected individuals, as they are mostly at a young and productive age, requiring a global approach and close monitoring, intended to improve quality of life, prevent disease progression and disability, and disease-related costs. It is with great pleasure that we conclude this special team work, with collaboration of many dedicated professionals who made the effort to provide such a complete issue on the Novel Targets For Therapeutic Intervention in Inflammatory Bowel Disease.