LAUSR

With this article we wanted to carry out an educational review about of the fundamental aspects related to the proposal of the existence of a peripheral sympathetic reflex regulated by Histamine, through its effect on presynaptic H3 type receptors, under the interaction of a sensory neurone that would be mediated by Substance P. In this respect, we consider it useful to highlight the role of Histamine, so we discuss some aspects about its history, metabolism, and function, as well as its interaction with H3 type receptors, considered as neuroreceptors, which define and typify it as a neuromediator at both levels of the nervous system, central and peripheral.