Carbon monoxide (CO) is one of endogenous gaseous messengers, or gasotransmitters, and as a paramount mediator in physiological and disease conditions. In this review, we focus on the functions of… Click to show full abstract
Carbon monoxide (CO) is one of endogenous gaseous messengers, or gasotransmitters, and as a paramount mediator in physiological and disease conditions. In this review, we focus on the functions of CO in the normal and pathological renal physiology. We discuss endogenous renal CO production and signaling in the normal kidney, the characteristic of CO-releasing molecules (CORMs) modalities, and outline of its regulatory functions in renal physiology. This article summarizes the mechanisms as well as the effect of CO in the evolving field of renal diseases. We predict numerous innovative CO applications to evolve in the cutting-edge scholarly future.
               
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