LAUSR

Osteoporosis is a typical localized or systemic skeletal disease in the clinic, mainly characterized by the weakness of bone formation and the increase of bone resorption, resulting in the decrease of bone mineral density (BMD), and frequently occurs in postmenopausal women. With the growth of the aging population, the risk of osteoporosis or even osteoporotic fracture brings great economic pressure on society and families. Although anti-osteoporosis drugs have been developed, there are still some side effects in the treatment group. Hence, that is a compelling need for more reasonable therapeutic strategies. Exosomes are nanosized extracellular vesicles (EVs), secreted by virtually all types of cells in vivo, which play an important role in intercellular communication. Compared with conventional drugs and stem cells transplantation therapy, exosomes have apparent advantages of lower toxicity and immunogenicity. Exosomes contain many functional molecules, such as proteins, lipids, mRNAs, microRNAs (miRNAs), which can be transferred into recipient cells to regulate a series of signaling pathways and influence physiological and pathological behavior. In this review, we briefly summarize the current knowledge of exosomes and the therapeutic potential of exosomal miRNAs derived from mesenchymal stem cells (MSCs), osteoblasts, osteoclasts, and macrophages in osteoporosis. Finally, a prospect of new treatment strategies for osteoporosis using new biomaterial scaffolds combined with exosomes is also given.