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BACKGROUND Self-assembled nanoclusters arrange the components into an organized structure for the nanoparticulate system and also in the transportation of cellular elements for the fabrication of microelectronic devices. Nanoclusters reduce transcytosis and increase endocytosis in intestinal mucin to strengthen the retrograde pathway that helped in the delivery of actives to the Golgi apparatus. OBJECTIVES This review article focuses on the self-assembled nanoclusters for cellular transportation, applications of self-assembled structures in the delivery of essential elements like the use of a peptide in targeted and stimuli-responsive drug delivery systems, self-assembly of tocopherol nanoclusters that promotes vitamin E delivery across the endothelial barrier. Methods Current innovation in the self-assembly of peptides includes the formation of nanostructures like vesicles, fibers, and rod-coil in the applications of wound healing, tissue engineering, treatment of atherosclerosis, in sensing heavy metals from biological and environmental samples and advanced drug delivery. RESULTS Self-assembled biodegradable nanoclusters are used as biomimetic structures for synergistic effect. Improvement in the methods of preparation like the addition of a copolymer is used for temperature-triggered drug release nanoclusters. CONCLUSION Green synthesis of nanoclusters, nanocluster-based biosensor and artificial intelligence are the future concept in the manufacturing and the prevention of toxicity in humans.