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Background LncRNAs have been reported to be involved in a variety of biological functions, including gene expression, cell growth, and differentiation. They may also serve as oncogenes or tumor suppressor… Click to show full abstract
Background LncRNAs have been reported to be involved in a variety of biological functions, including gene expression, cell growth, and differentiation. They may also serve as oncogenes or tumor suppressor genes in diseases. lncRNAs that can encode small nucleolar RNAs (snoRNAs) have been named small nucleolar RNA host genes (SNHGs). Objective In this review article, we readily review the regulatory mechanisms and clinical significance of Lnc SNHG4 in cancer. Methods We investigate systematically databases like Scopus, PubMed, Embase, Google Scholar, and Cochrane Library database for all research articles and provide an overview regarding the biologic functions and mechanisms of lncRNA SNHG4 in tumorigenesis. Results compared with neighboring normal tissues, SNHG4 is significantly up-regulated in various tumor tissues. SNHG4 Upregulation was mainly associated with advanced tumor stage, tumor size, TNM stage, and decreased overall survival. In addition, aberrant SNHG4 expression promotes cell proliferation, metastasis, migration, and invasion of cancer cells. Conclusion SNHG4 may serve as one new therapeutic target and prognostic biomarker in patients with cancer.
Journal Title: Current pharmaceutical design
Year Published: 2022
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