LAUSR

BACKGROUND More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects. METHODS Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up. RESULTS However, there are two technical issues of concern related to this method. First, the two solvents used for this approach must be miscible; concomitantly, the drug has to be soluble enough in a solvent but not in the antisolvent. Second, the particle growth needs to be adjusted by surfactant addition. CONCLUSION In this review, nanoprecipitation methods and solvent removal techniques for poorly water soluble drugs will be discussed.