LAUSR

Gliomas are the most prevailing intracranial tumors, which account for approximately 36% of the primary brain tumors of glial cells. Glioblastoma multiforme (GBM) possesses a higher degree of malignancy among different gliomas. The blood-brain barrier (BBB) acts as a protective shield of the brain against infections and toxic substances by preventing foreign molecules or unwanted cells from entering to brain parenchyma. Nano-carriers such as liposomes, nanoparticles, dendrimers, etc., boost the brain permeability of various anticancer drugs or other drugs. The favourable properties like small size, better solubility, and modifiable surface of dendrimers have proven their wide applicability in the better management of GBM. However, in vitro and in vivo toxicities caused by dendrimers have been a major concern. The presence of multiple functionalities on the surface of dendrimers enables the grafting of targte ligand and/or therapeutic moieties. The surface engineering leads to the improvement of certain properties like targeting effiecieny, pharmackinetic profile, therapeutic effect, and toxicity reduction. This review will be focused on the role of different surface modified dendrimers in the effective management of GBM.