LAUSR

The folate-modified graphene oxide (GO-FA) was successfully prepared, which had good stability and biocompatibility on rat glioma cells. The formation and composition of GO-FA were confirmed by scanning electron microscope (SEM), transmission electron microscope (TEM), fourier transform infrared spectrum (FT-IR), Raman spectra and X-ray photoelectron spectroscopy (XPS spectra). The cell experiment suggested good biocompatibility of GO-FA on rat glioma cells. The experiment of GO-FA loading with temozolomide (TMZ) showed that the maximum drug loading of GO-FA was 8.05 ± 0.20 mg/mg, with the drug loading rate of 89.52 ± 0.19 %. When TMZ was released from the folate-modified graphene oxide loading with temozolomide (GO-FA-TMZ), its release behavior in vitro showed strong pH dependence and sustained release property. The growth of rat glioma cells can be effectively inhibited by GO-FA-TMZ, with the cell inhibition rate as high as 91.72 ± 0.13 % at the concentration of 600 μg/mL and time of 72 h. According to the above experimental results, this composite carrier has potential applications in drug delivery and cancer therapy.