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Human Disease System Biology.

In recent years, genome-wide association studies (GWAS) and next-generation sequencing technologies have been widely used to detect the common genetic variants of diseases. Despite these successes, the majority of genetic… Click to show full abstract

In recent years, genome-wide association studies (GWAS) and next-generation sequencing technologies have been widely used to detect the common genetic variants of diseases. Despite these successes, the majority of genetic architecture of human complex diseases remains unknown. In the post-genome era, the major challenge is to mine novel disease risks from multi-level omics data using system biology methods, which may expand our knowledge of the causes of genetic disease.

Keywords: disease system; system biology; disease; biology; human disease

Journal Title: Current gene therapy
Year Published: 2018

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