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Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury.

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Curcumin is a naturally occurring polyphenol which is isolated from the rhizome of Curcuma longa (turmeric). This medicinal compound has different biological activities including antioxidant, antibacterial, antineoplastic, and anti-inflammation. It… Click to show full abstract

Curcumin is a naturally occurring polyphenol which is isolated from the rhizome of Curcuma longa (turmeric). This medicinal compound has different biological activities including antioxidant, antibacterial, antineoplastic, and anti-inflammation. It has also therapeutic effects for cancer, neurodegenerative disorders, renal disorders, and diabetes mellitus. Curcumin is safe and well-tolerated at high concentrations without making toxicity. In the present review, we demonstrated curcumin affects the Nrf2 signaling pathway to exert its therapeutic and biological activities.

Keywords: pathway induces; nrf2 pathway; curcumin activates; pathway; activates nrf2; curcumin

Journal Title: Current molecular medicine
Year Published: 2019

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