LAUSR

HERVs are humans endogenous retroviruses, which represent about 8% of human genome, and have various physiological functions, specially in pregnancy, embryo development and placenta formation. However, their involvement in diseases is not well defined. Some studies observed changes in HERVs expression according to age. Therefore, the aim of this systematic review was to analyze their role in pathogenesis and usage of diagnosis or prognosis biomarkers in aging disorders. I performed a search on the Pubmed interface for papers published from January 1953 to june 1st 2021. There was inclusion of 45 articles, which matched the eligibility criteria and evaluated the following diseases: breast cancer, prostate cancer, amyotrophic lateral sclerosis (ALS), osteoarthritis, Alzheimer disease, immunosenescence, cognitive impairment, cataract, glaucoma and hypertension. In conclusion, the results suggested that HERVs play a role in the pathogenesis and can be used as biomarkers for diagnosis or prognosis of aging disorders.