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OBJECTIVE The objective of current research work was to prepare chewable tablets having Acacia catechu extract useful for mouth ulcers using 32 factorial design. METHODS Acacia catechu heartwood extract was prepared using a reported method with some modifications. The extract was characterized using TLC against catechin marker. Then drug-excipients interaction studies were carried out. The mixture of drug and excipients were evaluated for pre-compression parameters. With the application of 32 factorial design, chewable tablets were prepared using direct compression technique. Prepared tablets were evaluated for post-compression parameters. RESULTS In vitrodrug release study of the developed formulations was investigated both in intact and crushed form of tablets. Based on in vitroperformance, the best formulations were selected (F6, F7 & F8 from intact and F1, F5 & F9 from the crushed group) and subjected to various kinetic models and evaluated for chewing difficulty index (CDI). CONCLUSION The overall results revealed that the formulated chewable tablets complied with the standards and exhibited a satisfactory performance in terms of drug release, chewing difficulty index and other related parameters.