LAUSR

BACKGROUND Type II diabetes mellitus is significant public health issues globally-type II diabetes inadequacies and serious adverse effects are associated with conventional medicines, herbal medicine as a path Setaria italica often known as foxtail millet, is a popular crop. Rice put into practice in many ways, and this crop seven has utilized in both sweet and savory meals. It is suitable as a meal for diabetes people in India due to its low gluten level. OBJECTIVE To evaluate antidiabetic, antihyperglycemic activity, histopathological change of type II diabetic rat, simultaneous determination of kaempferol and quercetin in foxtail millet (Setaria italica (L.) Beauv.) by validated high -performance thin layer chromatography. METHODS Five best-selected genotypes of FM K-1, K-4, K-5, K-6, K-7, K-10 was put to work out of 10 genotypes for the study that forced to endure to initial antidiabetic activity involving D.P.P.H. investigation, glycogen content, and histological investigation done with the rat organs liver, mussels & blood. Furthermore, experiments of seed aqueous extract performed via oral administration of Setaria italica seed aqueous extract (SISAE) in streptozotocin-induced diabetic rats and further compared using glibenclamide, a standard oral hypoglycemic agent. The effect of long-term treatment with 300 mg of S.I.S.A.E./kg body weight/day on blood glucose & glycemic control evaluated in normal and diabetic rats. RESULTS There was a significant decrease in fasting blood glucose associated with a significant improvement in glycemic control as evidenced by lower levels of HbA1c in diabetic treated rats when compared to those in untreated diabetic rats. The differences in the glycemic index determined among all the five genotypes of Setaria italica no significant alterations in liver gross found. However, minor cholesterol hemorrhage and lymphocytic infiltrations spotted in the liver of rats. CONCLUSION Experimental finding refers that the aqueous extract of Setaria italica seeds have excellent antihyperglycemic and has excellent potential as a source for natural health products.