LAUSR

BACKGROUND Robust evidence has described that Parkinson´s disease (PD) is associated with an increased risk for of developing epileptic seizures. In fact, an interplay between PD and epilepsy has been of interest for many years. An emerging hypothesis is that inflammation could link both diseases. OBJECTIVE Considering Bearing in mind the experience of our group in the field of Ca2+/cAMP signalling pathways, this article discussed, beyond inflammation, the role of these signalling pathways in theis link between PD and epilepsy. METHODS Publications involving Ca2+/cAMPsignalling pathways, PD, and epilepsy (alone or combined) were collected by searching PubMed and EMBASE. RESULTS The comprehension of the interplay between PD and epilepsy could improve the drug therapy. In addition, a Ca2+signallingsignaling dyshomeostasis due to Coronavirus disease 2019 (COVID-19), an emerging and rapidly evolving situation, has been reported. CONCLUSION Thus, this article also discussed debated recent findings about of therapeutics involving Ca2+ channel blockers for preventing Ca2+signallingsignaling dyshomeostasis due to COVID-19, including the correlation among COVID-19, epilepsy, and PD.