Phthalimide derivatives have been presenting several promising biological activities in the literature, such as anti-inflammatory and analgesic, antitumor, antimicrobial, anticonvulsant, among others. The most well known and studied phthalimide derivative… Click to show full abstract
Phthalimide derivatives have been presenting several promising biological activities in the literature, such as anti-inflammatory and analgesic, antitumor, antimicrobial, anticonvulsant, among others. The most well known and studied phthalimide derivative (isoindoline-1,3-dione) is thalidomide, because this compound initially presented important sedative effects. This review approaches some of the recent and efficient chemical synthesis pathway to obtain phthalimide analogues. It is also presented a summary of the main biological activities of these derivatives found in the literature. Therefore, this review describes the chemical and therapeutic aspects of phthalimide derivatives.
               
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