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Recent Updates on Synthesis, Biological Activity, and Structure-Activity Relationship of 1,3,4-oxadiazole-Quinoline Hybrids: A Review.

Due to their diverse applications in industrial and synthetic organic chemistry, quinoline and 1,3,4-oxadiazole have become important heterocyclic compounds. Quinoline and 1,3,4-oxadiazole compounds have been developed for various medical conditions… Click to show full abstract

Due to their diverse applications in industrial and synthetic organic chemistry, quinoline and 1,3,4-oxadiazole have become important heterocyclic compounds. Quinoline and 1,3,4-oxadiazole compounds have been developed for various medical conditions such as anti-cancer, anti-bacterial, anti-fungal, antimalarial, antioxidants, anti-HIV, anticonvulsant, antiviral, etc. The current review includes synthetic protocols for biologically active 1,3,4-oxadiazole incorporating quinoline hybrids with their structure-activity relationship to explore work (Mainly from 2010 to 2021) based on 1,3,4-oxadiazole-quinoline hybrids to the medicinal chemist for further research in the development of the molecule.

Keywords: structure activity; oxadiazole quinoline; activity relationship; activity; quinoline hybrids

Journal Title: Current organic synthesis
Year Published: 2022

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