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Beta-Blockers and Abdominal Aortic Aneurysm Growth: A Systematic Review and Meta-Analysis.

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BACKGROUND Aortic aneurysms are worrisome because of their predisposition to dissection and rupture. Beta-blockers are considered first line therapy for aortic aneurysms. The following meta-analysis assess if beta-blockers diminish aortic… Click to show full abstract

BACKGROUND Aortic aneurysms are worrisome because of their predisposition to dissection and rupture. Beta-blockers are considered first line therapy for aortic aneurysms. The following meta-analysis assess if beta-blockers diminish aortic aneurysm growth. METHODS A literature search was performed to collect information on clinical trials that have assessed aortic aneurysm growth between beta-blockers and placebo. The primary endpoint was aortic aneurysm growth rate per year. A forest plot with a random effects model was used for analysis. RESULTS Eight clinical trials were included in the analysis. Beta-blockers showed a statistically non-significant effect on aortic aneurysm growth (standard mean difference -0.44; 95% CI [-0.44, 0.00]). CONCLUSION Beta-blockers do not significantly influence aortic aneurysm growth. Further studies are required to find a suitable medical therapy to reduce growth rates.

Keywords: aneurysm growth; growth; beta blockers; aortic aneurysm

Journal Title: Current cardiology reviews
Year Published: 2020

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