LAUSR

Phthalazinones are important nitrogen rich heterocyclic compound that has been topic of considerable medicinal interest because of their diversified pharmacological activities. This versatile scaffold forms a common structural feature for many bioactive compounds, which leads to design and development of novel anticancer drugs with fruitful results. The current review article discusses the progressive development of novel phthalazinone analogues that are targets for various receptors such as PARP, EGFR, VEGFR-2, Aurora kinase, Proteasome, Hedgehog pathway, DNA topoisomerase and P-glycoprotein. It describes the mechanistic insights into anticancer properties of phthalazinone derivatives and also highlights various simple and economic techniques for synthesis of phthalazinones.