LAUSR

Cancer is considered as one of the leading causes of death in the world, especially patients with lung, pancreatic, or brain tumors are most likely to die of cancer and patients with prostate and breast cancer are at high risk of non-cancer death. As a result, there is on-going research regarding the development of new, safe and efficient anticancer agents. Coumarin-based naturally occurring compounds possess a broad spectrum of activity in medicinal chemistry such as anticancer, anti-inflammatory, antimicrobial, antioxidant agents, etc. Many researchers have synthesized coumarin-based novel therapeutic agents via molecular hybridization technique, which offers an excellent opportunity for development of novel compounds with improved biological activities by incorporating two or more pharmacophores. This review sheds light on the recent developments on coumarin based anticancer hybrid derivatives and their structure-activity relationships (SAR). This review serves as a medium that medicinal chemists could utilise for the design and synthesis of coumarin derivatives with significant pharmacological value as future anticancer agents.