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The mechanism of cephalosporin-induced convulsions is as follows: The inhibition of an inhibitory response caused by beta-lactam antibiotics is because that they bind directly to the receptor and inhibit GABA-induced… Click to show full abstract
The mechanism of cephalosporin-induced convulsions is as follows: The inhibition of an inhibitory response caused by beta-lactam antibiotics is because that they bind directly to the receptor and inhibit GABA-induced Clcurrentsd. β-lactam antibiotics produce convulsions via their GABA A antagonist properties. Alternatively, cephalosporins might induce convulsions by enhancing glutamatemediated excitatory neurotransmission, possibly by activating NMDA receptors, a subtype of glutamate receptors that have an important role in regulating seizure activity (5).
Journal Title: Iranian Journal of Child Neurology
Year Published: 2018
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