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Relationship of atherogenic index of plasma and mean platelet volume with ejection fraction in ischemic and nonischemic heart failure.

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AIM Our aim was to evaluate the relationship and diagnostic value of atherogenic index of plasma (AIP) and mean platelet volume (MPV) for heart failure (HF) and ejection fraction (EF).… Click to show full abstract

AIM Our aim was to evaluate the relationship and diagnostic value of atherogenic index of plasma (AIP) and mean platelet volume (MPV) for heart failure (HF) and ejection fraction (EF). MATERIALS AND METHODS In the present study, AIP and MPV were studied in 114 stable HF patients (48 ischemic [42.1%], 66 nonischemic [57.9%]) and 69 controls. RESULTS Mean AIP and MPV were significantly higher in HF compared with controls (p = 0.002; p = 0.03). In multivariate analysis, AIP and MPV were independently associated with EF. In receiver-operating characteristics (ROC) curve analysis both of them had optimal diagnostic value for HF. CONCLUSION AIP and MPV regardless of ischemic etiology, were significantly higher in HF compared with controls. Both AIP and MPV are independent predictors of EF and have cut-off values for diagnosis of HF.

Keywords: mean platelet; heart failure; platelet volume; atherogenic index; index plasma; aip mpv

Journal Title: Biomarkers in medicine
Year Published: 2019

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