LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

Differential circular RNA expression profiling during osteogenic differentiation of stem cells from apical papilla.

Photo from wikipedia

Aim: This study aimed to investigate the distinct expression pattern of circular RNAs (circRNAs) in stem cells from apical papilla (SCAPs) during osteogenesis. Materials & methods: Isolated SCAPs were cultured… Click to show full abstract

Aim: This study aimed to investigate the distinct expression pattern of circular RNAs (circRNAs) in stem cells from apical papilla (SCAPs) during osteogenesis. Materials & methods: Isolated SCAPs were cultured in growth medium or osteogenic medium, respectively. Total RNA was extracted and submitted to RNA-sequencing. Expression profiles of circRNAs and constructed circRNA-miRNA-mRNA networks were determined. Results: A total of 333 unregulated circRNAs and 317 downregulated circRNAs in osteogenic differentiation were detected. Bioinformatics analysis identified that several biological pathways may be associated with osteogenic differentiation of SCAPs. Moreover, ten circRNAs, 21 miRNAs and 19 mRNAs were selected to construct competing endogenous RNA networks. Conclusion: This study revealed that expression profiles of circRNAs were significantly altered and specific circRNAs might function as competing endogenous RNAs in SCAPs during osteogenic differentiation.

Keywords: rna; expression; osteogenic differentiation; cells apical; stem cells

Journal Title: Epigenomics
Year Published: 2019

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.