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AIM The development of surface-tailored quercetin (QCT)-salicylic acid (SA) physical complex for effective treatment of skin carcinoma. MATERIALS & METHODS QCT-SA nanomixed micelles were prepared by the self-assembly method employing… Click to show full abstract
AIM The development of surface-tailored quercetin (QCT)-salicylic acid (SA) physical complex for effective treatment of skin carcinoma. MATERIALS & METHODS QCT-SA nanomixed micelles were prepared by the self-assembly method employing the Quality by Design (QbD) approach and evaluated for various in vitro, ex vivo and in vivo parameters. RESULTS The optimized formulation showed enhanced percent permeation (Q24), in other words, 78.12 ± 0.47, improved in vitro cellular uptake and annexin-V-apoptosis assay exhibited 60.86% cell death. The 7,12-dimethylbenz(a)anthracene and histopathology protocol revealed the improved antineoplastic action of QCT. The dermatokinetic profile showed the maximum drug concentration (6 h), in other words, 416.02 ± 26 μg/cm2 in epidermis and 103.65 ± 12 μg/cm2 in dermis. CONCLUSION The overall performance ratified the safety and efficacy of optimized nanomixed micelless of QCT with SA in a synergistic manner.
Journal Title: Nanomedicine
Year Published: 2017
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