LAUSR

We previously reported that weight loss in patients with diabetes and obesity through real-world Intensive Lifestyle Intervention (ILI) is associated with significantly lower A1C for up to 5 years. However, it is unclear if baseline A1C has any impact on the magnitude of glycemic improvement in this population. Over 5 years, we evaluated a cohort of 129 patients with diabetes and obesity (90% type 2 diabetes, 67% female, mean age 53±10 years, diabetes duration 10±9 years, body weight 110±19 Kg, BMI 38±5.3 Kg/m2) enrolled in a 12-week ILI program. According to baseline A1C, we divided participants into group A with A1C 9% (15 patients, 11.6%, mean A1C 9.8±0.8%). Compared to baseline, body weight decreased at 5 years by 6.6 Kg, 9.6 Kg, and 8.3 Kg in groups A, B, and C, respectively (p Disclosure M. Tasabehji: None. S. Tomah: Stock/Shareholder; Self; Amarin Corporation. S. Ashrafzadeh: None. A. Mottalib: None. O. Hamdy: Advisory Panel; Self; AstraZeneca, Sanofi-Aventis. Consultant; Self; Abbott, Merck & Co., Inc. Research Support; Self; National Dairy Council. Stock/Shareholder; Self; Healthimation, LLC.