LAUSR

During pregnancy in type 1 diabetes, insulin requirements increase from the second trimester onward, reaching maximum in the third trimester. In twin pregnancies, the larger placental mass leads to elevated circulating levels of placental hormones, many of which have been attributed to the insulin resistance of pregnancy (1,2). Hence, higher insulin requirements are anticipated in twin pregnant women with type 1 diabetes. Only one study has reported longitudinal insulin requirements during twin pregnancy; the research showed larger increments in insulin doses until mid-gestation among twin pregnant women but no differences in absolute insulin requirements (3). A retrospective case-control study was undertaken in all identifiable twin pregnant women at Aarhus University Hospital between 2000 and 2018 ( n = 27) and 81 singleton pregnant women with type 1 diabetes, matched 1:3 on maternal age and year of delivery. Nine women had repeat pregnancies with twin and singleton pregnancies. Clinical data, insulin doses, and hemoglobin A1c (HbA1c) values were recorded. During the study period, guidelines for handling pregnant women with type 1 diabetes remained essentially unchanged. Data collection was approved by the regional health data …