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Eruptive Melanocytic Naevi Caused by Radotinib Therapy in Patients with Chronic Myeloid Leukaemia: 10 cases and a literature Review.

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Development of eruptive melanocytic naevi (EMN) is an uncommon phenomenon characterized by the sudden onset of hundreds of melanocytic naevi. EMN have been described after severe bullous diseases and administration… Click to show full abstract

Development of eruptive melanocytic naevi (EMN) is an uncommon phenomenon characterized by the sudden onset of hundreds of melanocytic naevi. EMN have been described after severe bullous diseases and administration of immunosuppressive drugs (1–5). The mechanism leading to EMN is unclear, but it is thought that an immunosuppressed state may play an important role (6). We describe here 10 cases of EMN in patients with chronic myeloid leukaemia (CML), all of which developed while receiving radotinib. Radotinib is a novel selective BCR/ABL tyrosine kinase inhibitor (TKI) for the treatment of CML with intolerance of other TKIs. To our knowledge, this is the first report of an association between radotinib therapy in patients with CML and the development of EMN.

Keywords: radotinib therapy; eruptive melanocytic; myeloid leukaemia; patients chronic; chronic myeloid; melanocytic naevi

Journal Title: Acta dermato-venereologica
Year Published: 2017

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