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Society for Publication of Acta Dermato-Venereologica Terbinafine, which targets squalene epoxidase (SQLE), has been used to treat dermatophyte infections for approximately 30 years. In 2017, a Swiss study reported that… Click to show full abstract
Society for Publication of Acta Dermato-Venereologica Terbinafine, which targets squalene epoxidase (SQLE), has been used to treat dermatophyte infections for approximately 30 years. In 2017, a Swiss study reported that 1% (16/1,644) of Trichophyton rubrum and 0.2% (1/412) of T. interdigitale were resistant to terbinafine (1). In 2019, we presented the first Japanese case of tinea unguium caused by a terbinafine-resistant T. rubrum isolate (Phe397Leu substitution), which was deposited as IFM 65760 (2). Our clinic obtained 3 terbinafine-resistant T. rubrum strains (Leu393Phe substitution) from 95 dermatophyte clinical isolates including T. rubrum (n = 62) and T. interdigitale (n = 33) in June 2020 (3). One strain (T. rubrum N79) was derived from a group home for individuals with intellectual disabilities. In this study, we examined the residents of this facility using mycological and molecular techniques to detect terbinafine-resistant T. rubrum strains.
Journal Title: Acta dermato-venereologica
Year Published: 2021
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