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BACKGROUND Stroke is a clinical syndrome of localized or global brain dysfunction caused by cerebrovascular disease. AIM This study aims to explore the effect of vitamin C acid stimulation on the rehabilitation process, nourishment state index and immune function indicators of stroke patients with dysphagia. DESIGN Prospective cohort. SETTING Hospital. POPULATION Stroke patients with dysphagia. METHODS A total of 120 stroke patients with dysphagia were randomly divided into a routine group and a test group, with 60 cases in each group. Routine swallowing training was performed in the routine group, and the test group was stimulated with vitamin C acid. The water swallow test (WST) and video fluoroscopic swallowing study (VFSS) were used to compare the rehabilitation of dysphagia in the two groups. Nourishment state index was evaluated by BMI, serum albumin, total serum protein and hemoglobin. Immune function index was evaluated by IgA, IgM and IgG. RESULTS Compared with the control group, the WST level of patients treated with vitamin C acid stimulation intervention were significantly reduced, and the VFSS score were significantly increased. Serum levels of hemoglobin, albumin, total protein, IgA, IgM and IgG in the vitamin C acid stimulation group were remarkably increased than those in the control group. CONCLUSION Vitamin C acid stimulation significantly improves rehabilitation of stroke patients with dysphagia, and ameliorates the nutritional status and immune function of patients.