LAUSR

Introduction Different devices have been released for closure of femoral vascular access after coronary angiography or percutaneous coronary intervention, whereas evidence about their efficacy and safety when compared with manual compression or head to head is lacking, especially across different diameters of sheaths, age and sex. Results A total of 30 studies were included in the analysis. Manual compression was evaluated as the control group in all of the included studies (5620 patients), Angioseal in 15 studies (17–29) (1812 patients), Exoseal in two studies (30–31) (1773 patients), Perclose in six (29, 32–37) (849 patients), Vasoseal in eight (36, 38–43) (699 patients), DUETT in one study (44) (392 patients), StarClose in two studies (23, 45) (334 patients), Techstar in two studies (37, 46) (252 patients) and extravascular staple in one study (47) (242 patients). At network meta-analysis, all the devices resulted as not superior to manual compression to reduce all vascular complications, and these results did not vary at metaregression for age, sex and diameter of sheaths. Manual compression significantly increased time to hemostasis when compared with Femoseal (5.72; 1.91–19.10), Vasoseal (5.11; 2.32–11.33), Perclose (3.46; 1.70–7.06), Angioseal (14.95; 7.84–28.57) and Techstar (9.78; 1.81–53.65), while was similar to StarClose, DUETT and Exoseal. Conclusion Different vascular devices for closure of femoral access did not results superior to manual compression to reduce complications, whereas offered a shorted time to hemostasis. StarClose was the device with the highest probability to perform best in terms of complication, whereas Angioseal was superior in terms of reduction of time to hemostasis.