LAUSR

BACKGROUND Symptomatic asthma and rhinitis negatively impact patients' work productivity and activity. However, little isknown about the potential interaction effect of both asthma and rhinitis control on work productivity and activity impairment. OBJECTIVE This study aimed to explore whether there are interaction effects of asthma and rhinitis control on work productivity and activity impairment in patients with asthma and with rhinitis. METHODS A total of 206 adult patients were prospectively recruited and were divided into four groups: both poorly controlled (BPC) (n = 53), poorly controlled asthma (PCA) with controlled rhinitis (CR) (n = 38), well controlled asthma with uncontrolled rhinitis (n = 43), and both well controlled (BWC) (n = 72) based on the symptom control status of asthma and rhinitis. Work productivity loss and activity impairment, asthma control, and rhinitis control were assessed by using work productivity and activity impairment questionnaire: general health, the asthma control test, and the rhinitis control assessment test, respectively. General linear regression models were used to study the contribution of asthma control, rhinitis control, and the interaction effect on work productivity and activity impairment. RESULTS Work productivity loss was most frequently reported in patients in the BPC group. Compared with the patients in theBWC group, the patients in the PCA-CR group had significantly higher activity impairment and worse asthma-related quality oflife (both p < 0.001). There were significant interaction effects of asthma and rhinitis control, which accounted for the increase in presenteeism, work productivity loss, and activity impairment (all p< 0.001). Although differences in absenteeism were not significant among the groups, there was a significant interaction effect of control levels accounted for absenteeism (p = 0.035). CONCLUSION Distinct interaction effects of asthma and rhinitis control reflected a link between upper and lower airways, which indicated that rhinitis control and the interaction effects of asthma and rhinitis control cannot be neglected during asthma management.