LAUSR

The present study was undertaken to explore the nephroprotective potential of Jatrophacurcas fruit extracts against carbon tetrachloride (CCl4) induced nephrotoxicity in rats. Nephrotoxicity was induced by CCl4 (3ml/kg body weight) in animals. Blood biochemical parameters, urine analysis and histopathological studies were carried out to assess the nephroprotective effect. CCl4 administration induced significant nephrotoxicity in rats, which was evident from enhanced levels of albumin, potassium.From the obtained results it may be concluded that pretreatment of silymarin (50mg/kg dose orally) significantly reversed carbon tetrachloride induced nephrotoxicitywhere asJatrophacurcas methanol extract (250mg/kg body weight) showed significant effect against CCl4 induced nephrotoxicity in rats thanJatrophacurcas aqueous extract (p<0.001) for most of the blood biochemical parameters, hematological parameters as well in attenuation of pathological changes in kidney tissues.