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An unusual nevus spilus and neurofibromatosis type 1.

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Sir, A growing wealth of clinical and molecular data supports the view that pigmented lesions such as segmentally arranged lentigines, segmentally arranged café-au-lait macules and giant café-au-lait macules can be… Click to show full abstract

Sir, A growing wealth of clinical and molecular data supports the view that pigmented lesions such as segmentally arranged lentigines, segmentally arranged café-au-lait macules and giant café-au-lait macules can be considered phenotypic variants of mosaic neurofibromatosis type 1. In a recent issue of the Indian Journal of Dermatology, Venereology and Leprology, Erdem et al. reported a case of Lisch nodules and pilocytic astrocytoma associated with large hypermelanotic patches lateralized on the right side of the body and featuring superimposed, scattered maculopapular naevi.1 Such cutaneous manifestations were labeled by the authors as “partial unilateral lentiginosis,” but are instead fully consistent with a diagnosis of papular nevus spilus. The histological features of lentigo simplex do not constitute a compelling argument since such pattern can very well be found in the macular speckles of papular nevus spilus.

Keywords: neurofibromatosis type; venereology; dermatology; nevus spilus; leprology

Journal Title: Indian journal of dermatology, venereology and leprology
Year Published: 2021

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