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Regulation of enzymatic activity is essential for living organisms. Nowadays, with the emergence of synthetic biology, there is a rising interest in placing the activity of synthetic catalysts under the… Click to show full abstract
Regulation of enzymatic activity is essential for living organisms. Nowadays, with the emergence of synthetic biology, there is a rising interest in placing the activity of synthetic catalysts under the control of a cell. This short review aims at summarizing the regulation strategies developed to date, and at presenting the development of an artificial zymogen, which is upregulated by a natural protease. In our view, this constitutes a first step towards the cellular control of the activity of an artificial metalloenzyme.
Journal Title: Chimia
Year Published: 2017
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